Lisa Sieverts

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Possible pathway for SARS-CoV-2 entry into the brain

My brother is a COVID-19 “long hauler,” suffering from brain fog and post-exertion malaise 6 months after he “recovered” from COVID. We’re trying to understand what’s happening to him.

The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors | bioRxiv

At both the adult and fetal stages, we detected a distinct pattern of SARS-CoV-2 entry associated genes’ transcripts in brain vascular endothelial cells and microglia, providing a potential explanation for an inflammatory response in the brain endothelium upon SARS-CoV-2 infection